Moellering Lab

Moellering Laboratory of Chemical Biology

We develop and apply chemical probes and proteomic technologies to target aberrant molecular signals in disease. 

Chemical Proteomics

Think global, probe local. Probes and platforms to interrogate protein function in native contexts.

Top Down Proteomic Profiling

Global interrogation of protein structure, function and organization in living cells. 

Exposing and Exploiting New Metabolic Signals

Integrated proteomic profiling of metabolic signaling to discover and target metabolism in disease. 

Synthesis of hyperstable biologics

New chemical strategies to mimic and manipulate bioactive protein domains. 

Who we are: The Moellering Lab is a multi-disciplinary group of scientists with training in chemistry, biochemistry, cell biology and mass spectrometry. We are uniquely situated in both the Department of Chemistry and the Institute for Genomics and Systems Biology at the University of Chicago – thus figuratively and physically bridging the physical and biological sciences. 

What we do: Research in the Moellering Lab lies at the interface of chemistry and biology, with an eye towards understanding and intervening in human disease. By integrating chemical synthesis, cell biology and mass spectrometry platforms, our research aims to identify novel biological mechanisms underlying diseases such as diabetes and cancer, and to subsequently develop innovative diagnostic and therapeutic modalities to impact these disorders. We are specifically interested in developing new chemical tools and technologies to study complexity and dynamics in the proteome, thus enabling targeted manipulation of protein targets and the pathways they govern. 

Lab News and Announcements

Open Positions: The Moellering Lab is seeking interdisciplinary researchers at the postdoctoral, graduate and undergraduate level. Check out our recent publications, as well as active areas of research, and contact us about current opportunities in the lab.


February 2020: Ray has been named a Sloan Fellow by the Alfred P. Sloan Foundation! This award is granted yearly to 126 early-career scientists from eight research fields. Read more from UChicago and the Sloan Foundation
December 2019:
Check out our recent paper in JACS on light-activated proximity profiling of protein “social networks” in cells. Congrats to David, Gihoon and co-authors!
December 2019: 
Ray has been awarded a CAREER Award from the National Science Foundation!! Read more about it here.